Relevance of host cell surface glycan structure for cell specificity of influenza A virus
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چکیده
7 1 Institute for Biophysics, Johannes Kepler University Linz, 4020 Linz, Austria 8 2 Center for Advanced Bioanalysis GmbH, A-4020 Linz, Austria 9 3 State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 1
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Membrane Environment Can Enhance the Interaction of Glycan Binding Protein to Cell Surface Glycan Receptors
The binding of lectins to glycan receptors on the host cell surface is a key step contributing to the virulence and species specificity of most viruses. This is exemplified by the viral protein hemagglutinin (HA) of the influenza A virus, whose binding specificity is modulated by the linkage pattern of terminal sialic acids on glycan receptors of host epithelial cells. Such specificity dictates...
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تاریخ انتشار 2017